PTU - Polskie Towarzystwo Urologiczne
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Article published in Urologia Polska 1997/50/2.


Stanisław Wroński
Katedra i Zakład Patomorfologii Klinicznej AM w Bydgoszczy
Kierownik Zakładu: prof. zw. dr hab. n. med. J. Domaniewski
Oddział Urologii Szpitala Wojewódzkiego im. dr J. Bizieła w Bydgoszczy
Ordynator Oddziału: dr n. med. Z. Jarzemski


kidney renal cell carcinoma lymphocyte cytotoxic activity


Objective. Immunotherapy is a new method of treatment in advanced renal cell
carcinoma. Authors compared IL-2 and IL-2 + BCG stimulation effect on cytotoxic
activity of the tumor infiltrating lymphocytes (TIL).
Material and method. Tumor infiltrating lymphocytes from 8 patients with renal
cell carcinoma were cultured with IL-2 alone and with IL-2 + BCG. The cytotoxic activity
of TIL was examined in autologic tumor cells cultures.
Results. The number of TIL-tumor infiltrating lymphocytes was the same in examined
cases. The cytotoxic activity of tumor infiltrating lymphocytes was higher after IL-2 +
BCG stimulation than after IL-2 stimulation alone.
Conclusion. BCG stimulation of tumor infiltrating lymphocytes allows to reduce the
amount of IL-2 and the cytotoxic effect is higher after BCG addition.


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