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THE INFLUENCE OF pH OF URINE ON THE PHARMACOKINETICS OF GENTAMICIN IN RABBITS
Article published in Urologia Polska 1989/42/4.

authors

Stanisław Dyderski
Z Katedry i Zakładu Farmacji Klinicznej Akademii Medycznej im. Karola Marcinkowskiego w Poznaniu Kierownik Katedry: prof. dr hab. farm. J. Masiakowski

summary

The author hvestigated the concentration of gentamicin in the serum of rab­bits after intramuscular administration of 10 mg in the Control group A, after acidification in group B and after alkalization of the urine in group C. On the grounds of the concentrations, the author calculated pharmacokinetics parameters. The analysis of dependence of the parameters on pH of the urine showed an increase in Cl, kel, shortening of to,5 and lowering Vd accompanying the increase in pH.

references

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