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The future of overactive bladder pharmacotherapy. Part I: opioid receptors, serotoninergic system, gamma- aminobutyric acid, gabapentin, vanilloid receptors, dopaminergic system, tachykinin receptors
Article published in Urologia Polska 2007/60/1.

authors

Tomasz Rechberger, Andrzej Wróbel
II Klinika Ginekologii Akademii Medycznej w Lublinie

keywords

urinary bladder, overactive bladder, pharmacotherapy

summary

Identification of suitable targets for pharmacologic intervention is essential for effective treatment of overactive bladder. With the present knowledge of the central and peripheral control of micturition, sites of action and drug mechanisms that can influence bladder function can be easily identified. The problem however is not only to inhibit bladder contraction, but to eliminate overactivity without disturbing normal micturition reflex. Muscarinic receptor antagonists are the mainstay of current treatments for the overactive bladder, however these exert severe side effects that result in the discontinuation of the treatment in a significant number of patients. Thus, there is an urgent need for the new treatments acting via alternative mechanisms. The basic pathophysiology of the bladder remains poorly understood compared with other systems of the body, but our knowledge on mechanism controlling lower urinary tract is still emerging. The following article considers some of the potential therapeutic approaches that are currently under investigation.

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correspondence

Tomasz Rechberger
II Klinika Ginekologii AM
20-090 Lublin
ul. Jaczewskiego 8
tel. 0691 376 307
wrobelandrzej@yahoo.com