The activity of ACHE in bladder muscle of the patients with bladder outflow obstruction
Article published in Urologia Polska 2002/55/2.
Tomasz Szydełko 1, Wojciech Apoznański 1, Zdzisław Woźniak 2, Anna Kołodziej 1, Janusz Dembowski 1, Romuald Zdrojowy 1, Tadeusz Niezgoda 1, Jarosław Kasprzak 1
- 1 Katedra i Klinika Urologii AM we Wrocławiu Kierownik kliniki: prof, dr hab. Jerzy Lorenz
2 Zakład Anatomii Patologicznej AM we Wrocławiu Kierownik zakładu: prof, dr hab. Jerzy Rabczyński
urinary bladder, parasympathetic system, acetylcholinesterase (ACHE)
- The objective. The authors evaluated the activity of the parasympathetic system of the urinary bladder in patients with BPH, who were treated with Hryntschak method. The indirect evaluation was based on the analysis of ACHE activity in bladder muscle, a sample of which was taken during the operation from the bladder top area.
- Material and method. Evaluations were made in 13 patients operated on because of BPH. The control group consisted patients with bladder cancer in whom no storage and voiding syndromes were detected before the operation and who underwent cystectomy. Samples were frozen in liquid nitrogen and then treated with mononuclear antibody against ACHE. The intensity of the reaction was assessed semiquantitativly.
- Results. ACHE was found to be more active in bladder muscle of patients with BPH.
- Conclusions. ACHE activity in bladder muscle may be used as a prognostic of surgical success and thus itmay serve to select patients for additional parasympathicolytic treatment.
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