CODE: 7.2 - Preoperative prediction of seminal vesicles involvement by prostate cancer
Article published in Urologia Polska 2006/59/Suplement 1.

authors

Jakub Dobruch ¹, Andrzej Borówka ¹, Przemysław Szostek ¹, Artur A. Antoniewicz ¹, Piotr Chłosta ², Tomasz Dzik ¹

¹ Klinika Urologii Centrum Medycznego Kształcenia Podyplomowego, I Zespół Dydaktyki Urologicznej - Oddział Urologii Międzyleskiego Szpitala Specjalistycznego w Warszawie
² Dział Urologii Świętokrzyskiego Centrum Onkologii w Kielcach

summary

Introduction. Invasion of seminal vesicles (SVI) revealed after radical prostatectomy is considered to be indicative of poor outcome associated with increased risk of biochemical failure and distant metastasis.

Objectives. The objective of this study was to determine the preoperative factors, which would allow to predict seminal vesicles invasion after radical prostatectomy.

Materials and methods. From January 2001 to May 2005, 107 men underwent radical prostatectomy due to clinically organ confined prostate cancer. Seminal vesicles invasion status was documented by histopathological examination of specimens. The relationship between SVI and other clinical and pathologic features was tested.

Results. Seminal vesicles invasion by prostate cancer was identified in 10 (9.3%) patients. Men with SVI had higher PSA (10 ?1.0 vs 9.6 ?3.3, NS) and PSAD values (0.35 ?0.2 vs 0.27 ?0.8, NS) in comparison to men without seminal vesicles infiltration. They also had greater biopsy (5.6 ?1.8 vs 5.2 ?1.2, NS) and specimens Gleason score (6.6 ?2.1 vs 5.5 ?1.2, NS) and prostate cancer percent in biopsy cores (73.7 ?6.3 vs 56.4 ?4.5, NS). These differences did not reach the level of significance. The patients with SVI were also more likely to have concomitant extracapsular extension (70% vs 36%).

Conclusions. Seminal vesicle infiltration is associated with unfavorable pathological prognostic factors. Based on clinical data it is not possible to predict eventual SVI after radical prostatectomy.