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CYTOGENETIC RESEARCHES IN TESTICULAR GERM CELL TUMORS
Article published in Urologia Polska 1999/52/3.

authors

Barbara Pieńkowska-Grela 1, Roman Sosnowski 2, Tomasz Demkow 2
1 Samodzielna Pracownia Cytogenetyki Centrum Onkologii w Warszawie
Kierownik pracowni: dr n. med. B. Pieńkowska-Grela
2 Klinika Nowotworów Układu Moczowego Centrum Onkologii w Warszawie
Kierownik kliniki: dr n. med. T. Demkow

keywords

testis testicular germ cell tumor chromosomal aberations isochromosome i(12p) ? results of treatment

summary

Malignant transformation may by caused by gene deregulation resulting from
specific chromosomal rearrangements. Adult testicular germ cell tumors (TGCT)
for clinical and pathological reasons divided in seminoma (SE) and non-
seminoma (NS), arise by transformation of germ cell. In most patients these
tumors are cured using cisplatin-based Combination chemotherapy. Important
steps in the TGCT oncogenesis seem to be polyploidization and formation of
the i(12p) marker chromosome. Cytogenetic studies have shown that
multiplication of 12p manifested in the i(12p) marker (in 80% of cases) or in
aberrant markers containing chromosome 12p material constitutes a uniąue
change in GCT which can be used as diagnostic marker. The consistent
amplification of critical 12p region in all histological subtypes of TGCT indicates
that this genetic abnormality could play an critical role in the ethiology, progres-
sion or prognosis of these tumors.

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