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KETOCONAZOL IN THE THERAPY OF ADVANCED PROSTATE CARCINOMA
Article published in Urologia Polska 1989/42/1.

authors

Jarowit Stolarczyk, Janusz Dembowski
Z Katedry i Kliniki Urologii Akademii Medycznej we Wroc³awiu Kierownik Kliniki: doc. dr hab. med. J. Stolarczyk

summary

A group of 5 patients with advanced prostate carcinoma were administered 1200 mg of ketoeonazol during 24h. In all the patients the authors observed a di­minution of the neoplasm size, regression of complete retention of urine or re­duction of retention in the bladder, multiple decrease in testosterone concentration and normalization or significant decrease in phosphatase activity. A fast analgetic reaction was observed in 2 patients. The results of the therapy show the useful­ness of ketokonazol in the therapy of prostate carcinoma. One patient had symp­toms of intolerance from the alimentary tract and the therapy was stopped. Exami-nations performed did not show a harmful effect of the drug on the function of kidneys, liver and haemopoietic system.

references

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