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THE EVALUATION OF THE CONTENTS OF LH AND FSH IN THE TISSUE OF THE PROSTATIC ADENOMA
Article published in Urologia Polska 1988/41/1.

authors

Waldemar Dorobek, Tadeusz Krzeski, Andrzej Borkowski, Stefan Zgliczyński, Bogusława Baranowska
Z Kliniki Endokrynologii CMKP w Warszawie Kierownik: prof dr hab. med. S. Zgliczyński
Z Kliniki Urologii AM w Warszawie Kierownik: prof. dr hab. med. T. Krzeski

summary

The purpose of the tests performed. in patients with the prostatic adenoma was to find out the presence of the gonadothropinas LH and FSH in the tissue of the prostatic gland. The analysis was based on 46 tissues of the prostatic ade­noma taken during adenomectomy, 12 tissues of the nucleus and 10 tissues of the sceletal muscle. The gonadothropins LH and FSH were measured radioimmunologically following their extraction from the tissue sediments (received by means of centnfuging of homogenates of the tissues examined). An average concentration of gonadothropins in the tissue of the prostatic adenome was: LH ? 117,5 mU/g of tissue (SE+10,5), FSH ? 33,7 mU/g of tissue (SE+3,8) and in the serum of the patients: LH ? 14,0 mU/ml (SE?1,1), FSH ? 2,3 mU/ml (SE+0,1). An average of the gonadothropins in the tissue of the nucleus was LH ? 147,2 mU/g of tissue (SE+17,8), FSH ? 133,8 mU/g of tissue (SE?18,3), and in the serum of the sick: LH ? 7,4 mU/ml (SE?0,8), FSH ? 3,1 mU/ml (SE?0,3).
The concentration of LH and FSH in the tissue of the prostatic adenoma ex-ceeded their concentrations in the serum. The concentration of LH in the pros­tatic adenoma did not differ significantly from that in the tissue of the nucleus. Finding out the presence of LH and FSH in the tissue of the prostatic adenoma in concentrations exeeeding those found in the serum may indicate that in the prostatic adenoma there are some mechanisms regulating the metabolism of andro­gens with the participation of LH and FSH.

references

  1. 1. Baranowska B., Zgliczyński S.: Prostatectomy-induced decrease in an en­
  2. hanced serum testosterone concentration in patients with prostatic hyperplasia and
  3. its pathophysiological imiplications. Endocr. Pol., 1979, XXX, 75. ? 2. Baranows­
  4. ka B., Zgliczyński S., Szymanowski J.: Les troubles de bilan hormonal chez les
  5. hommes porteurs d'un adenome prostatique. J. d'Urol., 1980, 86, 851. ? 3. Belis J. A.:
  6. Methodologic basis for the radioimmunoassay of endogenous steroids in human
  7. prostatic tissue. Investe. Urol.. 1980, 17, 332. ? 4. Diekman M. A., O'Callaghan P.,
  8. Nett T. M., Niswender G. D.: Validation of methods and quantification of luteal re­
  9. ceptors for LH throughout the estrous cycle and early pregnancy in ewes. Biol.
  10. Reprod., 1978, 18, 999. ? 5. Ekman P., Snochowski M., Dahlberg E., Bression D.,
  11. Hogberg B., Gustafsson J. A.: Androgen, progestin and estrogen receptors content
  12. in normal and hyperplastic human prostate. J. Clin. Endocr. Metab., 1979, 49, 205. ?
  13. 6. Flocks R. M.: Benign prostatic hypertrophy: its diagnosis and menagement. Med.
  14. Times N. Y., 1964, 92, 519. ? 7. Ghanadian R., Lewis J.G., Chisholm G.D., O Do-
  15. noghue E. P. N.: Serum dihydrotestosterone in patients with benign prostatic hy-
  16. perthrophy. Br. J. Urol., 1977, 49, 541. ? 8. Ghanadian R, Puah C.M.: Relationships
  17. between oestradiol-17B), testosterone, dihydrotestosterone and 5a-androstane-3a, 17|3-
  18. -dill in human benign hypertrophy ans carcinoma of the prostata. J.Endocr., 1981,
  19. 88, 255. ? 9. Harbitz T. B., Haugen O. A.: Histology of the prostate in elderly men.
  20. Acta path. microbial. scand. (A), 1972, 80, 756. ? 10. Huggins C: The etiology of
  21. benign prostatic hypertrophy. Bull N. Y. Acad. Med., 1947, 23, 696.
  22. 11. Huggins C, Hodges CV.: Studies on prostatic cancer. I. The effect of cas­
  23. tration, of estrogen and of androgen injection on serum phosphatase in metastatic
  24. carcinoma of the prostate. Cancer Res. 1941, 1, 293. ? 12. Isurugi K.F., Fukutani K.,
  25. Takayasu H. I., Nakabayashi K., Tamaoki B. I.: Age related changes in serum lu­
  26. teinizing hormone (LH) and follicle stimulating hormone (FSH) levels in normal
  27. men. J. clin. Endocr. Metab., 1974, 39, 955. ? 13. Krieg M., Bartsch W., Voigt K.D.:
  28. Binding metabolism and tissue levels of androgens in human prostatic carcinoma,
  29. benign prostate hyperplasia and normal prostate. Steroid Receptors. Metabolism and
  30. prostatic cancer. Schroder F. H. and de Voogt H. J. (eds), 1980, XX, 102, (Amster­
  31. dam: Excerpta Medica). ? 14. Leake A., Chisholm G. D., Habib F. K.: Characteri­
  32. zation of the prolactin receptor in human prostate. J. Endocr., 1983, 99, 321. ?
  33. 15. Lewis J. D., Ghanadian R., Chisholm G. D.: Serum 5a-dihydrotestosterone and
  34. testosterone changes with age in man. Acta endocr., 1976, 82, 444. ? 16. Midgley
  35. A. R.: Radioimmunoassay: a method for human chorionic gonadotropin and hu­
  36. man luteinizing hormone. Endocrinology, 1976, 79, 10. ? 17. Midgley A. R.: Radio­
  37. immunoassay for human follicle-stimulating hormone. J. clin. endocr. Metab., 1977,
  38. 27, 295. ? 18. Moore R. A.: Benign hypertrophy of the prostate. A morphological
  39. study. J. Urol., 1943, 50, 580. ? 19. Yamanaka H., Makino T., Yajima H., Saruki K.,
  40. Shida K.: Efficacy of (D-LEU)-DES GLY-NH10-LH-RH ethylamide against prosta­
  41. tic. Prostate, 1985, 6, 27. ? 20. Zięcik A., Shaw H.J., Flint A.P.E.: Luteal LH
  42. receptors during the oestrus cycle and early pregnancy in the pig. J. Reprod. Fert.,
  43. 1980, 60, 129.