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Mucosa-associated lymphoid tissue in genito-urinary tract
Article published in Urologia Polska 2007/60/3.

authors

Agnieszka Pastuszka, Ewa Ziółko, Wacław Kuczmik, Beata Marniok2, Konstanty ¦lusarczyk, Tomasz Lubas
Katedra i Zakład Anatomii Opisowej i Topograficznej w Zabrzu ¦l±skiej Akademii Medycznej w Katowicach

Katedra i Oddział Kliniczny Chorób Wewnętrznych w Bytomiu ¦l±skiej Akademii Medycznej w Katowicach

Katedra i Klinika Chirurgii Ogólnej i Naczyń ¦l±skiej Akademii Medycznej w Katowicach

Oddział Urologii Szpitala Specjalistycznego nr 1 w Bytomiu

keywords

genito-urinary tract, MALT mucosa-associated lymphoid, GUALT genito-urinary associated lymphoid

summary

Mucosa is a big surface of the human body that is exposed to different microorganisms. It is connected with the conception of MALT (Mucosa Associated Lymphoid Tissue), which collaborates with the general immunity system. The objective of the study is to discuss the MALT construction and function. The study presents the operation of Mucosa Associated Lymphoid Tissue in genito-urinary system and compares the human's mucosa immunity system with the rat mucosa immunity system, especially focusing on the bladder. The genito-urinary associated lymphoid tissue is a different immunity system in comparison to the general immunity system. This system is most effective with the immunization by external factor. It isn't active during an early phase of neoplasm process. We have noticed a different concentration of immunoglobulin in a rat. It is connected with physiologically different bacterial flora. The bladder have created its own mechanism of defense – „first line of defense” – as it is most exposed to infection.

references

  1. Płytycz B, Gliński ZF, Jarosz J i in: Immunologia porównawcza. Wydawnictwa Uniwersytetu Jagiellońskiego, Kraków 1999.
  2. Gowans JL, Knight EJ: The route of Re-circulation of limphocytes in the rat. Prc Roy Soc B 1964, 159, 257-282.
  3. James SP: Mucosal T-cell function. Gastroenterol Clin N America 1991, 20, 597-612.
  4. Ptak W: Podstawy immunologii. Podręcznik dla studentów medycyny. PZWL, Warszawa 1987.
  5. Roit L, Brostoff J, Male D: Immunologia, wyd. I, tłum. p. red. J. Żeromskiego Wydawnictwo Medyczne Słotwiński Verlag, Brema 1996.
  6. Weissamn IL: Limphocyte Homing Receptors and the Immune response in vivo. Byo Essays 1986, 5, 112-116.
  7. Klein J: Immunology. John Willey & Sons, New York 1982.
  8. Lefrancas L: Intraephitelial Limphocytes of the intestinal mucosa, chriouser & chriouser. Seminars in immunology 1991, 3, 99-108.
  9. Sim GK: Intraephitelial Lymphocytes and the Immune System. Advances in Immunology 1995, 58, 297-343.
  10. Mestecky J: The common mucosal immune system and crorent strategies for the induction of immune response in external secretions. J. Clin. Immunol., 1987.7, 265-276.
  11. Nair PN, Shroeder HE: Duct associated lymphoid tissue (DALT) of minor salivary glands & mucosal immunity. Immunology 1986, 57, 171-180.
  12. O�Sullivan NL. Skandera CA, Montgomery PC: Limphocyte Lineages at Mucosal Effector Sites: Rat Salivary Glands. The Journal of Immunology 2001, 166, 5522-5529.
  13. Mowat AM, Viney JL: The anatomical basis of intestinal immunity. Immunol Rev 1997, 156, 145-148.
  14. Jakubisiak M: Immunologia. PWN, Warszawa 1998, 336-354.
  15. Neutra MR, Pringault E, Kraehenbuhl JP: Antigen samdling across epithelial barriers&induction of mucosal immune responses. Ann Rev Immunology 1986, 14, 275-300.
  16. Kreachenbuhl JP, Nectra MR: Molecular & cellular basis of immune protection of mucosal surfaces. Physiol Rev 1992, 72, 4, 853-879.
  17. Foldi M: Physiologie und Pathophysiologie des Lymphgefassystems. w: Meessen H (red.) Lymphgefass-system, Springer Verlag, Berlin Heidelberg, New York, 1972, str. 239-310.
  18. Olszewski WL: Putting the Immune System Back in the Body. Lymphology 1988, 21, 83-85.
  19. Olszewski WL: What is Limphology-Prospects in Human Studies. Lymphology 1982, 15, 80-87.
  20. Olszewski WL: Surgical Pathophysiology of the Lymphatic system. Z Exp Chir 1981, 1 4, 9-20.
  21. Scelsi R, Scelsi L, Gritti A et al: Structure of the lymphatic microcirculation in the human urinary bladder with different intraluminal pressure and distension. Lymphology 1996, 29, (2), 60-66.
  22. Sim GK: Intraephitelial Lymphocytes and the Immune System. Advances in Immunology 1995, 58, 297-343.
  23. Krzeska I, Krzeski T: Nefropatia refluksowa u dzieci. PZWL, Warszawa, 1997.
  24. Neutra MR, Pringault E, Kraehenbuhl JP: Antigen samdling across ephitelial barriers & induction of mucosal immune responses. Ann Rev Immunol 1986, 14, 275-300.
  25. Ethart N, Desmoulins P-O, Chemian K et al: Dendritic Cell Recruitment and in Vivo Priming of CD 8 + CTL Inducted by Single Topical or Transephitelial Immunization Via the Buccal Mucosa with Measles Virus Nucleoprotein. The Journal of Immunology 2001, 167, 384-391.
  26. Kubota M, Miller, Imaoka K et al: Oral Immunization with Simian Immunodeficiency Virus p 55 gag and Cholera Toxin Elicits Both Mucosal JgA and Systemic JgG Immune Responses in Nonhuman Primates. The Journal of Immunology, 1997, 158, 5321-5329.
  27. McDermott MR, Bienenstock J: Evidence for a Common Mucosal Immunologic Systemand Migration of B Immunoblasts into Intestinal, Respiratory and Genital Tissues. The Journal of Immunology, 1994, 6, 572-583.
  28. Staats HF, Jackson RJ, Mamario M et al: Mucosal immunity to infection with implications for vaccine development. Current Opinion in Immunology 1994, 6, 572-583.
  29. Clifton VL, Husband AJ, Kay DJ: Local Immunity in the male reproductive tract. Immunol-Cell-Biol 1992, 70 (pt 5), 301-307.
  30. Ismail N, Bretsher PA: The Th1/Th2 Nature of Concurrent Immune Responses to Unrelated Antigens Ca be Independent. J Immunol 1999, 163, 4842-4850.
  31. Alpan O, Rudomen G, Matzinger P: The Role of Dendritic cells, B Cells, M cells in Gut-Oriented Immune Responses. J Immunol 2001, 166, 4843-4852.
  32. Poggi P, Marchetti C, Tazzi A, Scelsi R: The Lymphatic vessels and their relationship to lymph formation in the human urinary bladder. Lyphology 1995, 28 (1), 35-40.
  33. Scelsi R, Scelsi L, Gritti A et al: Structure of the lymphatic microcirculation in the human urinary bladder with different intraluminal pressure and distension. Lymphology 1996 29 (2), 60-66.
  34. Hendriks HR, Eestermans IL: Dissappearance and reappearance of high endothelial venules and immigrating lymphocytes in lymph nodes deprived of afferent lymphatic vessels: a possible regulatory role macrofages in lymphocyte migration. Eur J Immunol 1983, 13, 663-669.
  35. Azalli G, Orlandi G, Gatti R: The migration of lymphocytes and polymorphonuclear leucocytes across the endothelial wall of the absorbing peripheral lymphatic vassel. J Submicrosc Cytol Pathol 1990, 22 (4), 543-549.
  36. Kitamura T, Garofolo RP, Kamija A et al: Human Intestinal Epithelial Cells Express a Novel Receptor for IgA. J Immunol 2000, 164, 5029-5034.
  37. Marchetti C, Poggi P, Farina A et al: Structure of the initial lymphatics of human urinary bladder with invasive urothelial tumors. Lymphology 1996, 29 (3), 118-125.
  38. Pastuszka A: Tkanka limfatyczna w błonach �luzowych układu moczowo- -płciowego szczura. Rozprawa doktorska, �ląska Akademia Medyczna w Katowicach, Wydział Lekarski w Zabrzu, 2002,
  39. Hall M, Roser BJ, Dorsch FE: Sex steroid hormone regulation of IgA and IgG in rat uterine secretions. Nature 1977, 268, 534-536.
  40. Tourville DR, Ogra SS, Lippes J et al: The human female reproductive tract: Immunohistological localization of YA, YG, YM., secretory �piece�, and lactofferin. Amer J Obstet Gynec 1970, l, 1102-1108.
  41. Kutteh WH, Mastecky J: Secretory Immunity in the Female Reproductive Tract. AJRI 1994, 31, 40-46.
  42. Kutteh WH, Prince SJ, Hammond HR et al: Varations in immunoglobulins and IgA subclasses of human uterine cervical secretions around the time of ovulation. Clin Exp Immunol 1996, 104, 538-542.
  43. McDermott MR, Golgsmith CH et al: Lymphocytes in Genital Lymph Nodes Protect Mice From Intravaginal Infection with Simplex Virus Type 2. J Infect Dis 1989, 159, 460-466.
  44. Russell MW, Brown TA, Radl J et al: Assay of human IgA subclass antibodies in serum and secretions by means of monoclonal antibodies. J Immunol Methods 1986, 87, 87-93.
  45. Wold AE, Mestecky J, Tomana M et al: Secretory immunoglobulin A carries oligosaccharide receptors for Escherichia coli Type 1 fimbrial lectin. Infect Immunol 1990, 58, 3073-3077.
  46. Pisarski T: Położnictwo i ginekologia. Podręcznik dla studentów. PZWL, Warszawa 1993.

correspondence

Krzysztof Lubas
ul. Żuławska 5
42-200 Częstochowa
tel. 0 509 299 027
ktlubas@tlen.pl