PTU - Polskie Towarzystwo Urologiczne
home page
current numbers
archival numbers
list of articles:
list przewodni/covering letter
editor
Scientific Committee
publisher
subscription
advertising
important links

Gland volume and PSA PAP concentration in patients with BPH (benign prostatic hyperplasia)
Article published in Urologia Polska 1994/47/3.

authors

Jan Kulpa 2, Andrzej Bugajski 1, Ewa Wójcik 2, Janusz Jaszczyński 1
1 Zakład Analityki i Biochemii Klinicznej, Centrum Onkologii, Oddział w Krakowie
Kierownik: Dr chem. J. Kulpa
Dyrektor: Doc. dr hab. J. Skołyszewski
2 Katedra i Klinika Urologii, Collegium Medicum UJ w Krakowie
Kierownik: Doc. dr hab. med. A. Bugajski

summary

Group of 406 patients with BPH — 164 of them with inflamation lesion and 50 of them
with abscess have been examined. PAP and PSA concentrations have been observed and
described concerning age groups, volume and weight of the resected gland. Higher concent-
rations of PAP in plasma has been observed in 13,5% and that of PSA in 76,4% patients.
PSA concentrations depended on gland weight (r =0,387-p<0,001). No relationship
between PSA and PAP concentration and the patients\' age, and between the gland weight and
the patients\' age has been found. However, relationship between PSA and PAP concentration
r = 0,415 p<0,001
Inflamation lesion and abscess of BHP prostate gland have got influence on the increase of
PSA concentration as well as on gland volume.

references

  1. 1.Armitage T.G., Cooper E.H., Newling D.W.W., Robinson M.R.G., Appleyard /.: The value of the measurement of serum prostate specific antigen in patients with benign prostatic hyperplasia and untreated prostate cancer. Br. J. Urol., 1988, 62, 584. —
  2. 2. Bilhartz D.L., Tindall D.J., Oesterling J.E.: Prostate-specific antigen and prostatic acid phosphatase: Biomolecular and Physiologic characteristics. Urology, 1991, 38, 95.
  3. 3. Brawer M.K., Lange P.H.: Prostate-specific antigen: its role in early detection, staging, and monitoring of prostatic carcinoma. J. Endocr., 1989, 3, 227. —
  4. 4. Brown P.N., Speights V.O., Kuhl D., Riggs M., Spiekerman AM., McCord R.G., Coffield K.S., Stewart D.T., Und M.L.: Prostate-specific antigen levels from completely sectioned, Clinically benign, whole prostates. Cancer, 1991, 68,1592.
  5. 5. Carter H.B., Pearson J.D., Metler J.E., Brant L.J., Chan D.W., Andres R., Fozard J.L., Walsh P.C.: Longitudinal evaluation of Prostate-specific antigen levels in men with and without prostate disease. Jama, 1992, 267, 2215. —
  6. 6. Collins G.N., Lee R.J., McKefoie G.B., Rogers A.C.N., Henir M.\\\\ Relationship between prostate specific antigen, prostate volume and age in the benign prostate. Br. J. Urol., 1993, 71, 445. —
  7. 7. Cooner W.H., Mosley B.R., Rutherford CL., Beard J.H., Pond H.S., Bass R.B., Terry W.J.:Clinical application of transrectal ultrasonography and Prostate-specific antigen in the search for prostate cancer. J. Urol., 1988, 139, 758. —
  8. 8. Ferro M.A., Barnes /., Roberts J.B.M., Smith P.J.B.: Tumour markers in prostatic carcinoma. A Comparison of prostate — specific antigen with acid phosphatase. Br. J. Urol., 1987, 60, 69.
  9. 9. Geller J.: Basis for hormonal management of advanced prostate cancer. Cancer, 1993, 71 Suupl., 1039. — 10. Gittes R.F.: Carcinoma of the prostate. N. Engl. J. Med., 1991, 324, 236.
  10. 11.Heller J.E.: Prostatic acid phosphatase: its current clinical status. J. Urol. 1987, 137,1091.
  11. 12. Holmang S., Lindstedt G., Marin P., Hedelin H.:Serum concentration of Prostatic-specific antigen in relation t prostate volume in 50 healthy middle-aged men. Scand. J. Urol. Nephrol., 1993, 27, 15. —
  12. 13. Howanitz J.H.: Prostate specific antigen. Dis. Markers, 1993, 11, 3. —
  13. 14. Kane R.A., Littrup P.J., Babaian R., Drago J.R., Lee F., Chesley A., Murphy G.P., Mettlin C: Prostate-specific antigen levels in 1695 men without evidence of prostate cancer. Cancer, 1992, 69, 1201. —
  14. 15. Kulpa J., Marczyńska A., Wójcik E., Bugajski A., Leńko J.: Ocena stężenia swoistego antygenu sterczowego (PSA) w osoczu chorych na raka stercza. Urol. Pol., 1989, 42, 1.
  15. 16. Lee F., Torp-Pedersen S., Littrup P.J., McLeary R.D., McHugh T.A., Smid A.P., Stella P.J., Borlaza G.S.: Hypoechonic lesions of the prostate: clinical relevance of tumor size, digital rectal examination, and Prostate-specific antigen. Radiol., 1989, 170, 29. —
  16. 17. Leissner K.H., Tisell L.E.: The weight of the human prostate. Scand. J. Urol. Nephrol., 1979, 13, 137. —
  17. 18. Morote J., Ruibal A., Palou J., de Torres J.A., Soler-Rosello A.: Clinical utility of prostatic specific antigen and prostatic acid phosphatase serum levels in monitoring prostate cancer. Int. J. Biol. Markers, 1988, 3, 23. — 19. Oesterling J.E.: Prostate specific antigen: A critical assessment of the most useful tumor marker for adenocarcinoma of the prostate. J. Urol., 1991, 145, 907. —
  18. 20. Partin A.W., Carter H.B., Chan D.W., Epstein J.I., Oesterling J.E., Rock R.C., Weber J.P., Walsh P.C: Prostate specific antigen in the staging of localized prostate cancer: Influence of tumor differentiation, tumor volume and benign hyperplasia. J. Urol., 1990, 143, 747.
  19. 21. Pretlow T., Pretlow P.T., Yang B., Kaetzel CS., Delmoro C.M., Famis S.M., Bodner D.R., Kursh E., Resnick M.I., Bradley E.L.: Tissue concentrations of Prostate-specific antigen in prostatic carcinoma and benign hyperplasia. Int. J. Cancer, 1991, 49, 645. —
  20. 22. Rainwater L.M., Morgan W.R., Klee G.G., Zincke H.: Prostate-specific antigen testing in untreated and treated prostatic adenocarcinoma. Mayo Clin. Proc, 1990, 65, 1118. —
  21. 23.Stamey T.A., Yang N., Hay A.R., McNeal J.E., Frehia F.S., Redwin E.\\\\ Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. New Engl. J. Med., 1987, 317,909. —
  22. 24. Wang M.C, Loor R.M., Chu T.M.: Physico-chemical characterization of prostate antigen purified from human prostate gland and seminal plasma. Obst. Gynecol., 1983, 11, 327.
  23. 25. Weber J.P., Oesterling J.E., Peters CA., Partin A.W., Chan D.W., Walsh P.C.: The influence on serum Prostate-specific hyperplasia. J. Urol., 1989, 141, 987

correspondence

dr Jan Kulpa
Zakład Analityki i Biochemii Klinicznej,
Centrum Onkologii, Oddział w Krakowie
31-115 Kraków, ul. Garncarska 11