Estimation of the metotrexate therapy safety in patients with ileal neobladder
Article published in Urologia Polska 2001/54/2.

authors

Tadeusz Niezgoda ¹, Tomasz Szydełko ¹, Paweł Kowal ¹, Anna Wiela-Hojeńska ², Krystyna Orzechowska-Juzwenko ², Józefa Unolt ²

¹ Katedra i Klinika Urologii Akademii Medycznej we Wrocławiu
Kierownik: prof, dr hab. med. Jerzy Lorenz
² Katedra i Zakład Farmakologii Klinicznej Akademii Medycznej we Wrocławiu
Kierownik: prof, dr hab. med. Krystyna Orzechowska-Juzwenko

keywords

bladder, bladder carcinoma, ileal neobladdcr, chemotherapy

summary

Objective: The aim of this study was to investigate, wheather the applicatin of a Foley\'s catheter in patients with ileal neobladder was a sufficient method to avoid the reabsorption and prolonged excretion of metotrexate.

Material and method: This study was performed in the group of 5 patients with ileal neobladder and 9 patients with invasive carcinoma of the bladder, who formed a control group. The patients were treated with systemic polyche-motherapy, according to M-VAC scheme, because of the advancement of neoplasm desease. Serum concentration of metotrexate was measured at the end of the intravenous infusion of it and then 12, 24,48 and 72 hours after, with the use of immunofluorescent-polarising method and the analyser TDx. produced by Abbot.

Results: There were no statistically significant diffrerences in mean concentrations of metotrexate in the compared groups. There was no prolonged lime of exretion of metotrexate in the patients with ileal neobladder. drained with a Foley\'s catheter. Concentration of metotrexate did not reach critical values above which toxic signs, related to cheomotherapy with metotrexate were observed.

Conclusions: Drainage of urine with a Foley\'s catheter in patients with ileal neobladder prevents reabsorption and prolonged excretion of metotrexate.

references

correspondence