CODE: 8.2 - Value of photodynamic diagnosis (PDD) in evaluation of superficial bladder tumours in patients after ureteronephrectomy
Article published in Urologia Polska 2006/59/Suplement 1.

authors

Marek Lipiński, Leszek Jeromin, Kamil Burzyński, Waldemar Różański

II Klinika Urologii Uniwersytetu Medycznego w Łodzi

summary

Introduction. PDD method is the most precise way to get the picture of the neoplastic tissue. The urinary bladder is an organ which can be seen from inside, with all epithelial layer after the light insertion. The epithelial layer is the place, where pre-neoplastic and neoplastic changes appear most frequently.

Objectives. The aim of the study was to evaluate the value of photodynamic diagnosis after ureteronephrectomy in patients (pts) with renal pelvis and ureteral tumours.

Materials and methods. From 2001 to 2005 PDD was performed in 17 pts (9 men and 8 women) after ureteronephrectomy caused by renal pelvis and ureteral tumours. In all cysto-scopy in white light as well as PDD were performed. All PDD procedures were performed after instillation of 5 aminolevulinic acid solution (90 to 120 minutes before cystoscopy). To compare the images-both-white light of xenon lamp (300W) as well as UV (405nm) generated by D-Light STORZ, bladder mucosa was observed with special optic and the PDD system Storz camera. In first year of observations PDD was performed every 3 months. If there were no changes in PDD in next 2 years (every 6 months) and in next years once a year.

Results. Neoplasmatic lesions were seen in 6 pts only in PDD: after 3 months TaG3 in 1 and Cis in 1, after 6 months in 3 (2 Cis and 1 TaG2). After 12 months in 1 TaG2. Neoplasmatic lesions were treated by holmium laser ablation (in 2 pts) or by transurethral resection (in 4 pts).

Conclusions. Limited number of pts can not lead to ultimate conclusions, however the results encourage to affirm that PDD let for current diagnosis of urinary bladder neoplastic lesions in pts after ureteronephrectomy.