EARLY EFFECTS OF PHOTODYNAM1C THERAPY OF BLADDER TUMORS. PRELIMINARY REPORT
Article published in Urologia Polska 2000/53/2.

authors

Bogusław Wojciechowski ², Aleksander Sieroń ¹, Michał Szyguła ¹

¹ Ośrodek Diagnostyki i Terapii Laserowej Katedry i Oddziału Klinicznego Chorób Wewnętrznych i Medycyny Fizykalnej Śl. AM.
Kierownik Ośrodka: prof. dr hab. n. med. A. Sieroń
² Oddział Urologii Szpitala Miejskiego Nr 1 w Bytomiu
Ordynator: dr n. med. B. Wojciechowski

keywords

bladder bladder carcinoma photodynamic therapy

summary

Objective. In last years we may note an intensive development of treatment

methods of neoplasmatic diseases based on modern scientific discoveries. One

of them is termed photodynamic therapy (PDT). It leans on the interaction

between photosensitizer retained in tissue and laser light, which results in

cytotoxicity. PDT proved to be useful in the treatment of bladder cancer.

Patients and method. In the study 10 cases of bladder cancer were analysed.

Patients were treated in Laser Diagnosis and Therapy Center of Chair and Clinic

of Internal Deseases and Phisical Medicine of Silesian Medical University. Only

patients with superficial cancer (no infiltration of tunica muscularis) were

enrolled into the study.

Following 2 hours after the instillation of bladder with ALA solution, the

lesion was irradiated by laser light.

In order to estimate Pp level within the lesion the bladder was examined by

XILLIX system allowing detection of Pp fluorescence.

Results. In nine of ten examined patients regression of bladder tumor was

shown. In one case a progression of neoplasmatic process was observed and

therefore cystectomy had to be performed.

Conclusions. Photodynamic therapy in connection with other method may

provide in short-time follow-up good results in bladder cancer treatment.

It is necessary to continue observation of patients to observe late effects of

photodynamic therapy.

references