COMPARATIVE STUDIES OF THE INFLUENCE OF PERINATAL
ESTROGENIZATION ON MORPHO-FUNCTIONAL STATUS
OF THE ACCESSORY SEXUAL GLANDS IN MALE RAT
Article published in Urologia Polska 1998/51/4.
authors
-
Bolesław Otulakowski, Andrzej Limanowski 1, Bogdan Miskowiak 1
- Katedra i Zakład Anatomii Prawidłowej AM w Poznaniu
Kierownik Zakładu: prof. dr hab. W. Woźniak
1 Katedra i Zakład Histologii i Embriologii AM w Poznaniu
Kierownik Zakładu: prof. dr hab. A. Łukaszyk
keywords
-
male sexual glands ? neonatal period ? estrogenisation
summary
- Aim of the studies. The aim of these studies was to define the character
- of changes induced in accessory sexual glands of male rats by a single injection
- of estrogens on extrauterine day one and to compare the degree of sensitivity
- of the investigated organs on induced hormonal disturbances.
- Material and methods. The investigations were performed in male rats of
- Wistar strain, injected s.c. with a single dose of 1 mg of stilboestrol
- dipropionate (Polfa, Poland) on extrauterine day one. Three months after
- the injection the animals were sacrificed under ether anaesthesia and testes,
- epididymides, ventral prostate and seminal vesicles were examined
- histologically. Serum testosterone was determinated by RIA. The relative
- weight of the investigated organs and serum testosterone levels were
- statistically evaluated by Duncan test.
- Results. The estrogenization performed on day one of extrauterine life
- resulted in a significant reduction of the relative weight of all the organs
- tested. The testes of estrogenized animals reached 23.7%, epididymides 9.9%,
- ventral prostate 8.2% and seminal vesicles merely 6.8% of the relative weight
- of the control animals. Serum testosterone level in estrogenized animals
- decreased to about 50% compared with the control. In all hwestigated glands
- metaplasia of glandular epithelium into the multilayer and proliferation of
- connective tissue-muscular stroma was evidenced. The most pronounced
- changes were demonstrated in seminal vesicles, then in ventral prostate and
- caput epididymis. The changes in the duct of epididymis were least prono-
- unced.
- Conclusions. On the basis of the results obtained it was concluded that
- perinatal estrogenization leads to major morpho-physiological changes in
- accessory sexual glands; the most profound changes beeing observed in seminal
- vesicles, and the least profound in the duct of epididymis.
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