PTU - Polskie Towarzystwo Urologiczne
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Article published in Urologia Polska 1990/43/2.


Andrzej Borówka, Roman Pykało, Krzysztof Pych, Cezary Brzozowski
Z Katedry i Kliniki Urologii Instytutu Chirurgii AM w Warszawie Kierownik Katedry i Kliniki: prof. zw. dr hab. med. T. Krzeski
Dyrektor Instytutu: prof. dr hab. med. M. Szostek Z Zakładu Patomorfologii Instytutu Biostruktury AM w Warszawie
Kierownik Zakładu: prof. dr hab. med. S. Kru¶ Dyrektor Instytutu: prof. dr hab. med. K. Ostrowski


The objective of the study was observation of changes taking place in the tissues after injection of teflon paste and collagen gel (Zyplast Implant) below the bladder mucosa, The study was done on 18 rabbits, the follow-up was from 4 to 36 weeks. On the basis of autopsy examinations and histological examinations both substances were found to remain at the site of their injection throughout the whole follow-up without evoking any adverse reaction of the tissues. Teflon paste and collagen gel served as a biological supporting frame for the newly developing connective tissue. Both substances may be useful for injections through the urethra under the submucosal part of the ureter forelimination of vesicoure-teral reflux.


  1. 1. Cooperman L, S,, Mac Kinnon V., Bechler G.: Injectable collagen: A six--year clinical investigation. Anaesth. Piast. Surg., 1985, 9, 145. ? 2. Cooperman L. S., Michaeli D.: The immunogenity of injectable collagen: A one-year pro­spects study. J. Am. Acad. Derm., 1984, 10, 647. ? 3. Gelet A., Salas M,, Mar­tin X., Faure 3. L., Dubernard J. M.: Traitement endoscopique du reflux vesico--ureteral. J. d'Urol., 1987, 93, 263. ? 4. Kaplan W. E., Dalton D. P., Firlit C. R.: The endoscopic correction of reflux by politetrafluoroethylene injection. J. Urol., 1987, 138, 953. ? 5. Klingman A. M., Armstrong R. C: Histologic response to in­tradermal Zyderm and Zyplast (glutaraldehyde cross-linked) collagen injection in humans. J. Derm. Surg. Oncol., 1986, 12, 351. ? 6. Malizia A. A., Reiman H. M., Meyers R. P., Sande J. R., Barhams S,, Benson R. C, Davanjee M. K., Utz W. J.: Migration and granulomatous reaction after periurethral injection of Polytef. J. Am. Med. Ass., 1984, 251, 3277. ? 7. Mittelman R. E., Marracini J. V.: Pulmo­nary Teflon granulomas following periurethral Teflon injection for urinary in­continence. Arch. Pathol. Lab. Med., 1983, 107, 611. ? 8. O'Donnel B., Puri P.: Treatment of vesicoureteric reflux by endoscopic injection of Teflon. Brit. Med. J., 1984, 289, 7. ? 9. Puri P., 0'Donnel B.: Correction of experimentally produced vesicoureteric reflux in the piglet by intravesical injection of Teflon. Brit. J. Urol., 1984, 289, 5. ? 10. Schulman C. C, Simon J., Didier P., Avini F. E.: Endoscopic treatment of vesicoureteral reflux in children. J. Urol., 1987, 138, 950.
  2. 11. Szkarłat K.: Endoskopowe leczenie odpływu pęcherzowo-moczowodowego u dzieci. Urol. Pol., 1989, 42, 20. ? 12. Watson W., Kaye R. L., Klein A.: Injectable collagen: A clinical overview. Cutis, 1983, 31, 543. ? 13. Zyderm Collagen Implant. Physician Pacege Insert. Collagen Corporation. Palo Alto Ca., .1980.