PTU - Polskie Towarzystwo Urologiczne
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Article published in Urologia Polska 1987/40/4.


Jan Kulpa, Antonina Marczyńska, Jan Leńko, Marek Pawlicki, Andrzej Bugajski
Z Zakładu Analityki i Biochemii Klinicznej Centrum Onkologii
Instytutu im. M. Skłodowskiej-Curie, Oddział w Krakowie
Kierownik: prof. dr hab. med. A. Marczyńska
Z Kliniki Chemioterapii Centrum Onkologii Instytutu im. M. Skłodowskiej-Curie, Oddział w Krakowie
Kierownik: doc. dr hab. med. M. Pawlicki
Dyrektor: prof. dr hab. med. J. Skołyszewski
Z Kliniki Urologii Akademii Medycznej w Krakowie
Kierownik: prof. dr med. J. Leńko


In 71 patients treated for prostatic carcinoma the plasma !evel of TPA was determined before the treatment and serially after the operation assessing the value of this method as a supplementation of PAP determination. Initially raised plasma TPA level was observed in 36.6% of patients with prostatic carcinoma. A fairly far-reaching agreement was observed between TPA level and the clini­cal course, which was, however, much lower than for PAP. TPA determination was of certain Prognostic value since a higher proportion of positive results of the test was observed in the group of patients dying within two years. In about 80% of dying patients the concentration of at least one of these markers was raised.


  1. 1. Bjórklund B.: On the nature and clinical use of tissue polypeptide antigen (TPA). Tumor Diagnostik, 1980, 1, 9. ? 2. Griffiths J.C.: Prostate-specific acid phosphatase: Revaluation of radioimmunoassay in diagnosing prostatic disease. Clin. Chem., 1980, 26, 433. ? 3. Guinan P., Sadoughu N., John T., Albin R. J., Bush I. M.: The Prognostic value of carcinoembryonic antigen in carcinoma of the prostate. Urol. Res., 1974, 2, 79. ? 4. Huber P. R., Rist M., Hering F., Biedermann C, Rutishuer G.: Tissue polypeptide antigen (TPA) and prostatic acid phosphatase in serum of prostatic cancer patients. Urol. Res., 1983, 11, 233. ? 5. Kjellgren K.: The Prognostic significance of consecutive determinations of serum tissue polypep­tide antigen (TPA) in human breast cancer. Biomedical Carcino-Embryonic Pro­teins. vol. II. Ed. F. G. Lehmann, Elsevier-North-Holland Biomedical Press, 1979, 607. ? 6. Kulpa J., Kwinta A.: Kwaśna fosfataza sterczowa (PAP) w osoczu ? porównanie metody radio- i enzymoimmunologicznego oznaczenia stężenia. Urol. Pol., 1985, 38, 55. ? 7. Leńko J.: Rak stercza, Urol. Pol., 1984, 37, 245. ? 8. Leńko J. Kulpa J., Stefański W., Marczyńska A.: Serum carcinoembryonic antigen (CEA) and prostatic acid phosphatase by radioimmunoassay (PAP-RIA) in patients with prostatic cancer. Urol. Archiv., 1983, 21, 27. ? 9. Leńko J., Marczyńska A., Kulpa J., Kwinta A., Bugajski A.: Biochemical Control investigations (determinations of prostatic phosphatase ? carcinoembryonic antigen ? alkaline phosphatase) in pa­tients treated for prostatic carcinoma. Preliminary estimation of effectiveness. Ma­teria Medica Polona, 19,86, 18, 238. ? 10. Liithaens M., Schlegel G.: Verlaufskon-trolle mit Tissue ? Polypeptide Antigen und carcinoembryonalem Antigen in der radioonkologischen Nachsorge und Therapie. Tumor Diagnostik, 1981, 2, 179.
  2. 14. Marczyńska A., Kulpa, J., Leńko J., Augustyn M.: Serum tissue polypeptide antigen (TPA) and prostatic acid phosphatase (PAP) in patients with prostatic cancer. Intern. Urol. Nephrol., 1987, w druku. ? 12. Menedez-Botet C. J., Oettgen II. P., Pinsky C. N., Schwartz N. K.: A preliminary evaluation of tissue polypeptide antigen in serum or urine (or both) of patients with cancer or benign neoplasm Clin. Chem., 1978, 24, 868. ? 13. Mross K., Mross B., Wolfrum D.I.: Der Wert der TPA-Bestimmung bei malignom Patienten, Lab. Med., 1983, 7, 231. ? 14. Oehr P., Wustrow A., Derigs G., Borman R.: Evaluation and characterization of tumorasso-ciated antigen by the inverse distribution function. Tumor Diagnostik, 1981, 2, 195. ? 15. Pontes J. E.: Biological markers in prostate cancer. J. Urol., 1983, 130, 1037. ? 16. Rasmuson T., Bjork C. R, Damber L., Holm S. E., Jakubsson L., Jeppsson A., Stigbrand T., Westman G.: Tumor markers in bronchogenic carcinoma. Acta Ra­diol. Oncol., 1983, 22, 209. ? 17. Schwemmer B., Schiitz W., Kuntz R. M., Lehmwe A.: Simultaneous determination of six tumor markers in patients with prostatic car­cinoma and bladder tumors. Urol. Res., 1985, 13, 133. ? 18. Skryten A., Unsgaard B., Bjórklund B., Eklund G.: Serum TPA related activity in a wide Spectrum of cancer conditions. Tumor Diagnostik, 1981, 2, 117. ? 19. Woolf Ch. M.: Statistics for Biologists. Principles of biometry. D. Von Nostrand Comp. Inc., Toronto, London, Melbourne, 1968.