PTU - Polskie Towarzystwo Urologiczne
list of articles:

Article published in Urologia Polska 1986/39/4.


Marek Pawlicki, Piotr Koralewski, Bogumił Adamczyk
Z Kliniki Chemioterapii Centrum Onkologii Instytutu im. M. Skłodowskiej-Curie
Oddział w Krakowie
Kierownik Kliniki: doc. dr hab. med. M. Pawlicki Z Zakładu Analityki i Biochemii Klinicznej Centrum Onkologii Instytutu
im. M. Skłodowskiej-Curie Oddział w Krakowie
Kierownik Zakładu: prof. dr hab. med. A. Marczyńska
Dyrektor Centrum Onkologii Instytutu im. M. Skłodowskiej-Curie
Oddział w Krakowie: prof. dr hab. med. J. Skołyszewski


Seventy-seven patients with non-seminoma testicular tumours were given com­bined treatment including chemotherapy, radiotherapy and surgery. The patients were divided into two groups depending on the therapeutic method. In the first group of 38 cases treatment was given by the method of Einhorn (cisplatin, vin-blasttoie, bleomycin), to the second group the method of Samuels and Mathe was used (v!in,blastine, bleomycin, or vincristine and cyclophosphamide). The duration of follow-up was from 26 to 38 months.
The analysis of the results showed that in the group in good general condi­tion a higher proportion of remissions (88.0%) was obtained using more aggressive chemiotherapy of Einhorn than in those treated by the method of Samuels and Mathe (59.0%).
In the emaciated patients with Considerable weight loss the proportion of re­missions was similar, independently of the chemotherapeutic schedule (18.0% and 11.0% respectively) but the percent of complications was lower after treatment by the method of Samuels and Mathe after that of Einhorn.


  1. 1. Corden B.J., Fine R.L., Ozols R.F., Collins J.M.: Clinical pharmacology of high-dose cisplatin. Cancer Chemother. Pharmacol., 1985, 14, 1, 38. ? 2. Duchesne G., Peckham M.J.: Chemiotherapy and radiotherapy in advanced testicular nonsemino-ma. Radiotherapy Oncology, 1984, 1, 207. ? 3. Einhorn L.H.: Combination chemotherapy with Cisdichlorodia-mineplatiinum in disseminated testicular cancer. Can-cer treatment Rep., 1979, 63, 9?10, 1659. ? 4. Einhorn L. H., Donohue J.: Cis--diamminedichloroplatinum, Vinblastine, and Bleomycin Combination chemotherapy in disseminated testicular cancer. Ann. internal Medicine 1977, 87, 3, 293. ? 5. Karnofsky D. A., Abelman W. H., Craver L. F., Burchenal J. U.: The use of the Nitrogen Mustards in the paliative treatment of carcinoma. Cancer, 1948, Nov., 634. ? 6. Loehrer P. J., Einhorn L. H.: Cisplatin. Ann. intern. Med., 1984, 100, 704. ? 7. w książce: Oosterom A. T.: Therapeutic progress in ovarian cancer, testicular cancer and the sarcomas. Martinusi Nijhoff, London, 1980, 211. ? 8. Newlands E. S., Be-gent R. H. J., Kaye S. B., Rustin G. J. S., Bagshawe D. K.: Chemotherapy of ad­vanced malignant teratomas. Brit. J. Cancer, 1980, 42, 378. ? 9. Principles and Management of Urologic Cancer edited by Nasser Javadpour, National Cancer In-stitut, 1979. ? 10. Samuels M.L., Johnson D.E., Holoye P.Y.: Continuous intravenous bleomycin therapy with vinblastine in stage III testicular neoplasia. Cancer Che­mother. Rep., 1975, 59, 563.
  2. 11. Samuels M. L., Lanzotti V. J., Holoye P. Y., Boyle L. E., Smith T. L., Johnson D. E.: Combination chemotherapy in germinal cell tumours. Cancer treatment Re-vue, 1976, 3, 185. ? 2. Seber S., Schutte J., Niederle N., Schmidt C. C: Neue Er-gebnisse der Behandlung metastasierter Hodentumoren im Friih ? und Spatsta-dium. Tumor Diagnostic Theraipie, 1983, 2, 45. ? 13. Stoter G., Vendrik C.P.J., Struyvenberg A., Brouwers T. M., Sleyfer D. T., Koops H. S., Oosterom A. T., Pine-do H. M.: An update of the Dutch multicenter PVB-study in disseminated testi­cular non-seminomas. Martimus Nijhoff, London, 1980, 247. ? 14. Vugrin D., Whit­more W. E., Herr H. W., Sogani P., Golbey R.B.: VAB-6 Combination chemothe­rapy in resected stage II-B testis cancer. Cancer, 1983, 51, 1, 5.