PTU - Polskie Towarzystwo Urologiczne
home page
current numbers
archival numbers
list of articles:
list przewodni/covering letter
editor
Scientific Committee
publisher
subscription
advertising
important links

ASSESSMENT OF CHANGES IN BASIC PLASMA PROTEINS IN PATIENTS TREATED FOR PROSTATIC CARCINOMA
Article published in Urologia Polska 1986/39/3.

authors

Bogumił Adamczyk, Mieczysława Styrylska, Andrzej Bugajski, Maciej Augustyn
Z Zakładu Analityki i Biochemii Klinicznej Centrum Onkologii
Instytutu im. M. Skłodowskiej-Curie, Oddział w Krakowie
Kierownik Zakładu: prof. dr hab. med. A. Marczyńska
p. o. Dyrektora: prof. dr hab. med. A. Marczyńska
Z Katedry i Kliniki Urologii AM im. M. Kopernika w Krakowie
Kierownik: prof. zw. dr med. J. Leńko

summary

The concentration of total protein and its electrophoretic fractions was de­termined before treatment in 171 cases of prostatic carcinoma, 201 cases or pro­static adenoma, and 66 healthy men. The results before the treatment were compared with those in male patients in the same age range treated for gastric carcinoma, lung carcinoma and Hodgkin's disease. In 75 cases of prostatic carci­noma these values were repeatedly determined at intervals of 8?12 weeks.
The pattern of serum proteins in cases of prostatic carcinoma is a different one than that observed in other neoplasms. Its characteristiic feature is hypoalbu-minaemia related to the progression of the neoplasm, and a high level of alpha2-globulins, higher than in cases of other neoplasms. The changes ta plasma pro­teins are similar in prostatic carcinoma and an prostatic adenoma, but the intensity of hypoalbuminaemia was greater in carcinoma, and that of alphazglobulinaemia in adenoma. An important effect on the development of hypoalbuminaemia was not only a reduction of albumin level in the circulating plasma but also plasma dilution. A tendency for counteracting hypoalbuminaemia and for reduction of increased alpha2globulin level may be useful for the evaluatkin of successful treatment.

references

  1. 1. Ablin R. J., Gonder M. J., Soanes W. A.; Serum proteins in prostatic cancer,
  2. I. Relationship between clinical stage and level. J. Urol. 1973, 11*0, 238. ? Ablin
  3. R. J., Soanes W. A., Bronson P. M., Gonder M. J.: Serum proteiins in patients with
  4. beningn and malignant diseases of the prostate. Neoplasma, 1971, 18, 3, 271. ?
  5. 3. Ablin R- J., Gonder J., Soanes W. A.: Levelis' of immunoglobulins dn the serum
  6. of patients with carcinoma of the prostate. Neoplasma, 1972, 1, 19, 57. ? 4. Ablin
  7. R. J., Soanes W. A., Gonder M. J.: Serum proteins in prostatic cancer. IV Altera-
  8. tions and clinical resiponse following cryoprostatectomy. Urol. Int., 1979, 34, 339. ?
  9. 5. Adamczyk B.: Metoda oceny charakteru zamian białek surowicy krwi u chorych
  10. na nowotwory złośliwe na podstawie wyników uzyskanych za pomocą elektroforezy
  11. bibułowej. Nowotwory, 1976, 26, 2, 85. ? 6. Adamczyk B.: Poziom białek surowicy
  12. krwi ludzi zdrowych w przebiegu życia. Nowotwoiry, 1977, 27, 2, 147. ? 7. Adam­
  13. czyk B.: Zmiany w białkach surowicy krwi u chorych na nowotwory złośliwe
  14. o różnej lokalizacji. Nowotwory, 1978, 28, 2, 191i. ? 8. Briere R. C, Muli J. D.:
  15. Ełectrophorefslis of serum proteins with cellulose acetate. Am. J. Clin. Path., 1964,
  16. 42, 5. 547. ? 9. Gomall A. G., Bardawill C. J., David M. M.: Determination of
  17. serum proteins by means of biuret reaction. J. Biol. Chem., 1949, 177, 751. ?
  18. Wł. Leńko J.: Rak stercza. Urol. Pol., 1984, 37, 245.
  19. 11. Marczyńska A., Adamczyk B., Leńko J.: Serum proteins in patients with
  20. benign prostatic hyperplasia. Inter. Urol. Nephrol., 1983, 15, 1, 15. ? 12, Oszacki J.,
  21. Marczyńska A., Adamczyk B., Leńczyk M.: Obraz białek surowicy krwi, a zaawan­
  22. sowanie procesu nowotworowego! u chorych z rakiem żołądka. Nowotwory, 1967,
  23. 17. 4. 333. ? 13. Woolj Ch. M.: Statistics for biologists. Principles of biometry,
  24. O. Van Noestrand Comp. Inc, Toronto, London, Melbourne, 1968.