Piotr Bryniarski, Mariusz Wróblewski, Krzysztof Pliszek, Andrzej Potyka, Krzysztof Borkowski, Michał Tkocz, Mieczysław Fryczkowski, Wiesław Duda, Zofia Salska, Andrzej Paradysz
- Katedra i Klinika Urologii w Zabrzu ¦l±skiego Uniwersytetu Medycznego w Katowicach
Oddział Urologii, Szpital im. E. Michałowskiego w Katowicach
Oddział Urologii Szpitala Wojewódzkiego w Bielsku-Białej
Oddział Urologii Szpitala Wojewódzkiego w Rybniku
Introduction. Previous studies about the influence of obesity on PSA serum concentration in patients who underwent screening tests for carcinoma of prostate (CaP) showed, that increase body weight results in lower PSA concentration, which might affect the detection of CaP.
Material and methods. We analyzed 574 patient with CaP, who underwent radical prostatectomy in 2000-2007. Body weight, preoperative PSA serum concentration and postoperative Gleason score were assessed. All patients are under continuous control in urological out-patients clinic. Biochemical recurrence was diagnosed when PSA exceeded the concentration of 0.2 ng/ml. We computed the relation PSA/body weight. This factor was compared between groups of patients with and without biochemical recurrence after radical prostatectomy. We decided to examine the relation between PSA/body weight factor and postoperative Gleason score in the whole group of patients as well.
Results. Biochemical recurrence was diagnosed in 90 patients. The average score of PSA/body weight factor in the group of patients with recurrence was 0,283575861 in and 0,169424619 in the group of patients without recurrence. The difference between groups was statistically significant (p=0.000014). The correlation between PSA/ body weight factor and postoperative Gleason score is weak and positive (Spearman rank correlation = 0.137216).
Conclusion. 1. PSA/body weight factor assessed preoperatively may be a good prognostic of the increase risk of biochemical recurrence after radical prostatectomy. 2. This factor has the positive correlation with postoperative Gleason score, but the correlation is so weak that we cannot use in practice. 3. The subsequent studies with PSA/ body weight factor are needed to evaluate its real value of increased risk of biochemical recurrence.