PREVENTION OF SUPERIFCIAL BLADDER TUMOURS
RECURRENCES TREATED WITH TRANSURETHRAL
ELECTRORESECTION
Article published in Urologia Polska 1999/52/2.
authors
-
Piotr Kaczmarek, Eugeniusz Miękoś, Jerzy Niemirowicz, Waldemar Różański
- Klinika Urologii I. CH. WAM w Łodzi
Kierownik Kliniki: prof.dr hab. n.med. E. Miękoś
Oddział Urologii Zarządu Służby Zdrowia MSW w Łodzi
Ordynator: dr n. med. Jerzy Niemirowicz
keywords
-
bladder neoplasma immunotherapy
summary
- Introduction. Proper methods of superfcial bladder neoplasms treatment
- depend among others on both, the degree of bladder wall infiltration and cellular
- anaplasia. The treatment of such a disease resolves itself to tumour
- electroresection and intrabladder infusions in order to prolong the period of
- tumour remission or to counteract neoplasm recurrence.
- Aim Assessment of the efectiveness of preparations such as adriblastyna,
- epirubicyna and BCG suspension applied in the continuation of superficial
- bladder neoplasms treatment.
- Material and method. Assessment of the effectiveness ofrespective
- preparations was performed in 212 patients allotted into four groups
- dependently on the kind of the applied Preparation and the control group with
- no Preparation administered. The preparations were applied in the form of
- intrabladder instylations.
- Results. Significant dependency was found among particular groups of
- patients and the control group. However, the highest efficacy was observed in
- the group in which BCG suspension was applied.
- Conclusions. Application of preparations in the form of intrabladder
- instylations significantly prolongs the neoplasm rate remission the most effective
- is BCG suspension.
references
- [1] Boccafoshi, C, Montefiore, F., Pavesi, M., Pastormelo, M., Betta, P.:
- Late effects ofintravesical BCG immunotherapy on bladder mucosa infiltrating. Eur. Urol.
- 1995,27,334-338.
- [2] Bowyer, L., Hall, R. R., Reading, ]., Marsh, M.: The persistence of bacille
- Calmette-Guerin in the bladder after intravesical treatment for bladder cancer. B. J.
- Urol. 1995, 75, 2,188-92.
- [3] Fellows, G. J., Parmar, M. K? Grigor, K. M? Hall, R. R., Heal, M.R.,
- Wallace, D. M.: Marker tumour response to Evans and Pasteur BCG in multiple
- recurrent pTa/pTl bladder tumours. Br. J. Urol. 1994, 73, 6, 639-644.
- [4] Kaczmarek, R, Miękoś, E., Kaczmarek, ].: Instylacje dopęcherzowe z zawie-
- siny prątka BCG w leczeniu powierzchownych guzów pęcherza moczowego (pgpm).
- Urol. Pol. 1995, 3,189-193.
- [5] Keampfer, R., Gerez, L., Farbstein, H., Madar, L., Hirschman, O., Nus-
- sinovich, R., Shapiro, A.: Prediction of response to treatment in superficial
- bladder carcinoma through pattern of interleukin-2 gene expression. J. Clin. On-
- col. 1996,1778-1786.
- [6] Lamm, D. L., Thor, D. E., Stogdill, V. D., i wsp.: Bladder cancer immuno-
- therapy. J. Urol. 1982,128, 931-935.
- [7] Mack, D., Frick, J.: Low-dose BCG in superficial cancer with strain Connaught
- Canada - as ejfective as strain Pasteur Paris. Eur. J . Cancer 1994, 30 A, 11,1728-
- 1729.
- [8] Nista, A., Mattioni, M., Gismondi, A., Palmieri, G., Santoni, A.: Beta 1
- - intergin expression and function in human bladder cancer cells: Modulation by
- TNF alpha. Anticancer Research 1996, 2, 581-588.
- [9] Pryor, K., Goddart, J., Goldstein, D., Strickeer, P., Russell, R, Golo-
- vski, D., Penny, R.: BCG enhances monocyte and lymphocyte - mediated blad-
- der toumor cell killing. Br. J. Cancer 1995, 71, 801-807.
- [10] Ribera, M., Bielsa, ]., Mantrrola, J. M., Fernandez, M. T., Ferrandiz,
- C: Mycobacterium bovis - BCG infection of the glans penis: a complication of
- intravesical administration of BCG. Br. J. Dermatol. 1995,132, 309-310.
- [11] Salman, T., Elahmady, O., Elshafee, M., Omar, S., Salman, I.: Cathep-
- sin-D and TNF-alpha in bladder cancer. Disease Marcers 1996,4, 253-259.
- [12] Sander, B., Damm, O., Gustafsson, B., Andersson, U., Hacansson, L.:
- Localization of Il-l, 11-2, 11-4, 11-8 and TNF in superficial bladder tumors treated
- with intravesical BCG. J. Urol. 1996,156.
- [13] Schellhammer, P. F, Ladaga, L. E, Fillion, M. B.: Bacillus Calmette-Guerin
- for superficial transitional cell carcinoma of the bladder. J. Urol. 1986,135, 261-
- 264.
- [14] Thanhuser, A., Bohle, A., Scheider, B., Relling, N., Mattern, T., Ernst,
- M., Flad, H. D., Ulmer, A. J.: The induction of bacillus-Calmette-Guerin-
- actwated killer cells reguires the presence of monocytes and t-helper type-1 cells.
- Cancer Immunol. Immunother. 1995, 40,103-108.
|