Botulinum toxin application in children with overactive
and/or spastic detrusor – preliminary report Article published in Urologia Polska 2008/61/4.
authors
-
Janusz Sulisławski, Wiesław Urbanowicz
- Klinika Urologii Dziecięcej Collegium Medicum Uniwersytetu Jagiellońskiego
keywords
-
children neurogenic bladder detrusor overactivity botulinum toxin
summary
- Introduction.
Neurogenic disorders of the urinary bladder in children are in most cases due to myelomeningocele. Standard therapy is
- not effective in about 10% patients. These cases require surgical procedures such as urinary bladder augmentation. These procedures
- are associated with surgical and metabolic complications.
-
- The aim of the study.
This is a preliminary report of the use of botulinum toxin in children “resistant” to standard therapy with type
- III neurogenic urinary bladder.
-
- Material and methods.
Among 212 children with neurogenic bladder, classical therapy was not effective in 20 cases. All these
- cases were children with type III neurogenic bladder. In these cases botulinum toxin A was injected into detrusor at 10-12 U/ kg b.w.
- dose, but the total dose did not exceed 300 U. Therapeutic effects was assessed by cystometric investigations performed monthly
- throughout a 9 month period. Moreover, control VCUG was executed after 3 months. T-test for relative variables was used for statistical
- evaluation of the obtained parameters.
-
- Conclusions.
Type A botulinum toxin is safe and do not provokes any side effects. Statistically, it results in the improvement of cystometric
- investigation parameters. Temporary action of the BTx A present the limitation of this treatment method. Its use allows to
- postpone the decision concerning extensive surgical procedure – urinary bladder augmentation in children.
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correspondence
Janusz Sulisławski
Klinika Urologii Dziecięcej
ul. Wielicka 265
30-663 Kraków
tel. (012) 657 21 31
klinurol@gmail.com
sulislawski@gmail.com
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