PTU - Polskie Towarzystwo Urologiczne
list of articles:

Efficacy of hialuronic acid in painful bladder syndrome management
Article published in Urologia Polska 2007/60/3.

authors

Piotr Radziszewski, Albert Gugała, Tomasz Borkowski, Andrzej Borkowski
Katedra i Klinika Urologii Akademii Medycznej w Warszawie

keywords

urinary bladder, interstitial cystitis, treatment, hialuronic acid

summary

Introduction. Interstitial cystitis (painful bladder syndrome) is diagnosed after exclusion of other causes leading to similar symptoms. The main symptoms are pain, urgency, frequency and reduced cystometric capacity. In the therapy of interstitial cystitis oral agents, intravesical agents restoring the damaged urothelium (e.g. hyaluronic acid) and surgical methods are used. The aim of the studies. The aim of our study was to evaluate the influence of 8 weeks hialu-ronic acid therapy on the urinary bladder symptoms in patients with painful bladder syndrome. Patients and methods. 6 women aged from 27-80 years with painful bladder syndrome last-ing for 1 year to 17 years were qualified for the studies. Patients had performed 8 weekly in-stillations of a solution containing 40 mg of hialuronic acid (Cystistat, Bioniche, Canada). The treatment efficacy was evaluated by visual analogue scale (VAS) for pain and urgency. Addi-tionally patients filled the O'Larry Saint questionnaire. The evaluation was performed before and 7 days after the 8 weeks treatment.
Results.
5 patients finished the full 8 instillations treatment cycle. One patient received only 5 instillations due to E.coli infection. During the treatment the pain complains were reduced by 25%, urgency by 21% and the quality of life improved by 22% (quality of life dependant from the disease) and by 13% (quality of life dependant from symptoms) respectively. Except one episode of symptomatic urinary bladder infection no other side effects were observed.
Conclusions.
Hialuronic acid intravesical instillations are effective therapeutic option in the therapy of painful bladder syndrome and should be used before the decision about more ag-gressive therapy

references

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correspondence

Piotr Radziszewski
Klinika Urologii AM
ul. Lindleya 4
02-005 Warszawa
tel. (022) 502 17 02
pradziszewski@neostrada.pl