The development of arterial blood supply of human kidney during embryonic period
Article published in Urologia Polska 2007/60/1.
- Katedra i Klinika Urologii i Onkologii Urologicznej Akademii Medycznej w Poznaniu
Katedra i Zakład Anatomii Prawidłowej Akademii Medycznej w Poznaniu
kidney, metanephros, renal artery, vascular urogenital net, embryonic period
- Introduction. The development of the metanephros, mesonephros and gonad is strictly related one to another. Their normal development depends on proper formation of arterial supply. In available literature there is some differences in opinions about formation of arterial supply to the metanephros.
- The aim of the study. The aim of the study is to evaluate the external renal blood supply during embryonic period, establish the time of formation of the proper renal artery and determine the level of renal artery during changes in the location of the kidney.
- Material and methods. Study was made on 55 human embryos in developmental stages from 13 to 23. Age of embryos was established according to international criteria for developmental stages. All embryos were embedded in paraplast and sectioned serially in 3 planes. Sections were stained according to routine histological methods.
- Results. In stages 13 and 14, metanephros, gonads and mesonephros are supplied by common urogenital vascular net, formed by arteries from the aorta. In stages from 15 to 20 metanephros is additionally supplied by small arteries from the aorta. In stages 21 and 22 suprarenal arteries play a role in formation of the urogenital vascular net. In these stages the proper renal artery is finally observed. In stage 23 the urogenital vascular net is reduced in function and supply only mesonephros and gonad. At that time metanephros and suprarenal gland have their own arteries.
- Conclusion. Till the end of the 7th week of embryonic period, metanephros is supplied by urogenital vascular net, Small direct arteries from the aorta to the metanephros are also observed in that time. From the beginning of the 8th week metanephros is supplied by the renal artery. The renal artery which goes to the hilum of the metanephros is one of the upper mesonephric arteries which primarily supplies both metanephros and mesonephros. After the involution of the mesonephros it supplies only metanephros.
- Kosiński H: Unaczynienie tętnicze nerek u człowieka. Rozprawa habilitacyjna. Bibl Uniw Med, Łódź. 1994, 1-250.
- Bartel H: Embriologia. Wydawnictwo Lekarskie PZWL, Warszawa 2004.
- Bielańska-Osuchowska Z: Zarys organogenezy. Różnicowanie się komórek w narządach. Wydawnictwo Naukowe PWN, Warszawa 2004.
- Herzlinger D: Renal stem cells and the lineage of the nephron. Annu Rev Physiol 1994, 56, 671-689.
- Torrey TW: The early development of the human nephros. Contr Embryol Carneg Inst, 1954, 35, 175-197.
- Torrey TW: Morphogenesis of the vertebrate kidney. W: DeHahn R. L., Ursprung H. (eds) Organogenesis. Reinehart and Winston, New York 1965, 559-579.
- O´Rahilly R, Muecke EC: The timing and sequence of events in the development of the human urinary system. Z Anat Entwicklungsgesch 1972, 138, 99-109.
- O´Rahilly R, Müller F: Human embryology and teratology. 3rd ed. Willey-Liss Publ. New York, Brisbone, Singapore, Toronto 2001.
- Jirasek JE: Development of the genital system and male pseudohermaphroditism. Johns Hopkins Press. Baltimore 1971.
- Shikinami J: Detailed form of the Wolffian body in human embryos of the first eight weeks. Contrib Embryol Carnegie Inst 1926, 18, 49-61.
- Gage SP: A three weeks human embryo with special reference to the brain and nephric system. Am J Anat 1905, 4, 409-443.
- Politzer G: Die Entwicklung des Wolffschen Ganges beim Menschen. Acta Anat 1953, 18, 343-360.
- Silverman H: Über die Entwicklung der Epithelplatten in den Corpuscula renalia der menschlichen Urniere. Acta Anat 1969, 74, 36-43.
- Grobstein C: Inductive interaction in the development of the mouse metanephros. J Exp Zool 1955, 130, 319-340.
- Gruenwald P: The mechanism of kidney development in human embryos as revealed by an early stage in the agnesis of the ureteric buds. Anat Rec 1939, 75, 237-247.
- Saxen L, Koskimies O, Lathi A et al: Differentiation of kidney mesenchyme in an experimental model system. J Adv Morphogen 1968, 7, 251-293.
- Saxen L, Sariola H: Early organogenesis of the kidney. Pediatr Nephrol 1987, 1, 385-392.
- Felix W: The development of the urogenital organ. W: Keibel F, Mall EP, (eds): Manual of human embryology. Vol. II. Philadelphia and London 1912, 341-360.
- Taylor GP: Kidney and urinary tract. W: Dimmick JE, Kalousek DK (eds) Developmental pathology of the embryo and fetus. J. B. Lippincott Co. Philadelphia 1922, 579-604.
- Gościcka D, Szpinda M, Kochan J: Akzessorische Nierenarterien bei menschlichen Feten. Ann Anat 1996, 178, 559-563.
- Dyson M: Urinary system. W: Bannister LH, Berry MM, Collins P, Dyson M, Dussek JE, Ferguson MWJ (eds). Gray´s anatomy. Churchill Livingstone. Edinburgh, London, New York, Philadelphia, Sidney, Toronto 1995, 199-217.
- Edwards JG: The development of the efferent arteriole in the human metanephros. Anat Rec 1951, 109, 495-501.
- Speller AM, Moffat DB: Tubulovascular relationships in the developing kidney. J Anat 1977, 123, 487-500.
- Szpinda M, Kochan J, Molski S: Arterial kidney anastomoses in human fetuses. Med Sci Monit 1999, 5, 21-24.
Klinika Urologii i Onkologii Urologicznej
ul. Szwajcarska 3
tel. (061) 873 94 28