Use of photodynamic method in diagnosis and in efficacy of transurethral resection
of superficial bladder tumours Article published in Urologia Polska 2001/54/1.
authors
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Marek Lipiński, Leszek Jeromin
- Klinika Urologii Instytutu Chirurgii Akademii Medycznej w Łodzi Kierownik Kliniki: prof, dr hab. mcd. Leszek Jeromin
keywords
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urinary bladder, carcinoma, photodynamic diagnosis, 5 aminolevulinic acid, treatment, transurethral resection
summary
- Objectives. Early diagnosis of urinary bladder tumours is essential for effective treatment. Photodynamic phenomenon is caused by 5-ALA, which is a precursory of fluoroscopic porfiryncs that arc visible in the ultraviolet (UV) light after they entered a tumour cell. 5-ALA has a great value in early diagnosis of superficial bladder tumours, because it makes it possible to recognize early stages of tumours invisible in ordinary light used in cystoscopy.
- Material and methods. 61 patients (pts) with biopsy confirmed bladder tumour were cystoscopically (123 procedures) observed under 5-ALA instillation. Results were assessed in ordinary light and UV-Light Storz and additionally in laser light in 9 pts. 40 pis were observed after transurethral resection of tumours (TUR).
- Results. 21 pts (12 after TUR) had fluorescent areas, visible in UV-Light or laser only. 24 pts (15 alter TUR) without changes in normal cystoscopic light, presents red fluorescent areas in UV-Light with atypical changes confirmed histologically. In 16 pts (including 13 alter TUR) no changes were observed in normal and UV-Light.
- Conclusion. Use of 5-ALA allowed for the early diagnosis of superficial bladder tumours and made radicality of endoscopic operation.
references
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correspondence
Marek Lipiński
Klinika Urologii I Ch AM w Łodzi ul. Pabianicka 62. 93-513 Łódź
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