THE EFFECT OF THE EXTRACORPOREAL SHOCK WAVE
LITHOTRIPSY (ESWL) ON URINARY EXCRETION
OF GLYCOSAMINOGLYCANS IN PATIENTS WITH KIDNEY STONE
Article published in Urologia Polska 2000/53/1.
authors
-
Iwona Kaznowska-Bystryk, Tadeusz Sadowski 1, Dariusz Rzedzicki 1
- Katedra i Zakład Biochemii Klinicznej Akademii Medycznej w Lublinie
Kierownik Katedry: prof. dr hab. J. J. Tomaszewski
1 Oddział Urologii Wojewódzkiego Szpitala Specjalistycznego w Lublinie
Ordynator Oddziału: dr n. med. T. Sadowski
keywords
-
kidney kidney stones ESWL glycosaminoglycans
summary
- Introduction. We studied differences in excretion of glicosaminoglycans (GAG)
- between patients with kidney stone and a control group, evaluation of the
- extracorporeal shock wave lithotripsy (ESWL) effect on excretion of total GAG
- and evaluation of usefulness of urine GAG levels as a renal damage index
- after ESWL.
- Material and method. We studied 49 patients, aged 22-82, and treated with
- ESWL. Twelve hours urine samples were collected the day before and
- consecutively on the 1 and 5 day after treatment. A control group of 25 healthy
- persons, aged 24-66, was investigated at the same intervals. An assay of GAG
- was made according to the Farandel's method, creatynine levels were
- determined according to the Jaffs reaction.
- Results. A statistically significant decrease in urinary excretion of GAG was
- noted in patients with kidney stone compared to the control group and it was
- 0.66 mg/12 h (2.30 mg/g creatynine) and 1.55 mg/12 h (3.41 mg/g creatynine)
- respectively. The excretion of GAG in the group of patients with kidney stone
- decreased to 0.37 mg/12 h (1.03 mg/g creatynine), the day after lithotripsy
- and it returned to 0.64 mg/12 h (1.82 mg/g creatynine) 5 days after treatment.
- Conclusions. 1. A statistically significant decrease of urinary excretion of GAG
- has been noted in the group of patients with renal stone before ESWL treatment
- compared to the control group.
- 2. In our study excretion of GAG decreased the day after lithotripsy and it
- returned to its initial values within 5 days after treatment.
- 3. Monitoring of the urine GAG excretion after ESWL treatment has predictive
- value for the rate of repairing processes in the damage of mucus layer.
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