PTU - Polskie Towarzystwo Urologiczne
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THE EFFECT OF THE EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY (ESWL) ON URINARY EXCRETION OF GLYCOSAMINOGLYCANS IN PATIENTS WITH KIDNEY STONE
Article published in Urologia Polska 2000/53/1.

authors

Iwona Kaznowska-Bystryk, Tadeusz Sadowski 1, Dariusz Rzedzicki 1
Katedra i Zakład Biochemii Klinicznej Akademii Medycznej w Lublinie
Kierownik Katedry: prof. dr hab. J. J. Tomaszewski
1 Oddział Urologii Wojewódzkiego Szpitala Specjalistycznego w Lublinie
Ordynator Oddziału: dr n. med. T. Sadowski

keywords

kidney kidney stones ESWL glycosaminoglycans

summary

Introduction. We studied differences in excretion of glicosaminoglycans (GAG)
between patients with kidney stone and a control group, evaluation of the
extracorporeal shock wave lithotripsy (ESWL) effect on excretion of total GAG
and evaluation of usefulness of urine GAG levels as a renal damage index
after ESWL.
Material and method. We studied 49 patients, aged 22-82, and treated with
ESWL. Twelve hours urine samples were collected the day before and
consecutively on the 1 and 5 day after treatment. A control group of 25 healthy
persons, aged 24-66, was investigated at the same intervals. An assay of GAG
was made according to the Farandel's method, creatynine levels were
determined according to the Jaffs reaction.
Results. A statistically significant decrease in urinary excretion of GAG was
noted in patients with kidney stone compared to the control group and it was
0.66 mg/12 h (2.30 mg/g creatynine) and 1.55 mg/12 h (3.41 mg/g creatynine)
respectively. The excretion of GAG in the group of patients with kidney stone
decreased to 0.37 mg/12 h (1.03 mg/g creatynine), the day after lithotripsy
and it returned to 0.64 mg/12 h (1.82 mg/g creatynine) 5 days after treatment.
Conclusions. 1. A statistically significant decrease of urinary excretion of GAG
has been noted in the group of patients with renal stone before ESWL treatment
compared to the control group.
2. In our study excretion of GAG decreased the day after lithotripsy and it
returned to its initial values within 5 days after treatment.
3. Monitoring of the urine GAG excretion after ESWL treatment has predictive
value for the rate of repairing processes in the damage of mucus layer.

references

  1. [1] Alkibay, T., Karabas, O., Hizel, N.: Urinary GAG excretion following extra-
  2. corporeal shock wave lithotripsy. Int. Urol. Nephrol. 1993, 25, 321-326.
  3. [2] Atahan, O., Alkibay, T., Karaoglan, U., Deniz, N., Bozkirli, I.: Acute
  4. bioeffect of electromagnetic lithotripsy. Scand. J. Urol. Nephrol. 1996, 30, 269-
  5. 272.
  6. [3] Atahan, O., Kaigil, O., Hizel, N., Yavuz, O.: Urinary glycosaminoglycan
  7. excretion in bladder carcinoma. Scand. J. Urol. Nephrol. 1996, 30, 173-177.
  8. [4] Buffington, C. A., Blaisdell, J., Binns, S., Woodworth, B.: Decrease urine
  9. GAG excretion in cats with interstitial cystitis. }. Urol. 1996,155,1801-1804.
  10. [5] Ericson, D. R., Oddille, S., Martin, A., Bhavanandan, V. P.: Urinary
  11. chondroitin sulfates, heparan sulfate and total sulfated glycosaminoglycans in in-
  12. terstitial cystitis. J. Urol. 1997, 157, 61-64.
  13. [6] Farndale, R. W., Buttle, D. J., Barrett, A.: Improwed ±uantitation and dis~
  14. crimination of sulphated glycosaminoglycans by use of dimethylmethylene blue.
  15. Biochim. Biophys. Acta 1986, 883, 173-177.
  16. [7] Fellstrom, B., Becman, U., Danielson, B., Wikstrom, B.: Treatment of
  17. renal calcium stone disease with the synthetic glycosaminoglycan pentosan polysul-
  18. phate. World J. Urol. 1994, 12, 52-54.
  19. [8] Grases, R, Llompart, I., Conte, A., Coll, R., March, I. G.: Glycosamino-
  20. glycans and oxalocalcic urolithiasis. Nephron. 1994, 68, 449-453.
  21. [9] Hesse, A., Wuzel, H., Vahlensieck, W.: Significance of glycosaminogly-
  22. cans for the formation of calcium oxalate stones. Am. J. Kidney Dis. 1991, 4,
  23. 414-419.
  24. [10] Hurst, R. E.: Structure, function, and pathology of proteoglycans and glycosami-
  25. noglycans in the urinary tract. World J. Urol. 1994, 12, 3-10.
  26. [11] Jacson, R., Busch, S., Cordin, A.: Glycosaminoglycans: molecular proper-
  27. ties, protein, interactions, and role in physiological processes. Physiol. Rev. 1991,
  28. 71, 481-526.
  29. [12] Karlsen, S. ]., Berg, J. K.: Acute changes in renal function following extracor-
  30. poreal shock wave lithotripsy in patients with a Solitary functioning kidney.
  31. J. Urol. 1991, 145, 253-256.
  32. [13] Michelacci, Y. M., Glashan, R. Q.: Urinary eicretion of glycosaminoglycans
  33. in normal and stone forming subjects. Kidney Intern. 1989, 36, 1022-1028.
  34. [14] Parson, C. L.: A model for the function of glycosaminoglycans in the urinary
  35. tract. World J. Urol. 1994, 12, 38-42.
  36. [15] Rubben, H., Friedrichs, R., Stuhlsatz, H., Cosma, S., Lutzeyer, W.:
  37. Quantitative analysis of glycosaminoglycans in urothelium and bladder of calf.
  38. Urology 1983, 6, 655-657.
  39. [16] Winter, P., Ganter, K., Leppin, U., Schoeneich, G., Hesse A.: Glycosami-
  40. noglycans in urine and extracorporeal shock wave lithotripsy. Urol. Res. 1995,
  41. 23, 401-405.