ASSESSMENT OF THE RECEPTOR ACTIVITY OF T-LYMPHOCYTES IN ROSETTE TESTS IN PATIENTS WITH PROSTATIC CARCINOMA AND ADENOMA Article published in Urologia Polska 1984/37/4.
authors
-
Gabriel Turowski, Zygmunt Dobrowolski, Adam Kwinta
- Z Pracowni Immunologii Transplantologicznej III Katedry Chirurgu Ogólnej AM
w Krakowie
Kierownik Pracowni: prof. dr hab. G. Turowski
Z Katedry i Kliniki Urologii AM w Krakowie
Kierownik: prof. zw. dr med. J. Leńko
summary
- The receptor activity was studied in peripheral blood lymphocytes in 56 patients with prostatic adenoma and 104 cases of prostatic carcinoma. The active TEa rosette test and the total TEt rosette test were used. In patients with prostatic adenoma a statistically significant fall was observed of the lymphocyte count with a decrease in their receptor activity in both tests. This may be helipful in the assessment of the immunological status before surgical treatment.
- In patients with prostatic carcinoma a significant decrease of the lymphocyte count was observed with a simultaneous rise in the leucocyte count in the peripheral blood. The rosette activity of lymphocytes was significantly decreased in both tests and decreased further with progression of the disease.
references
- 1. Adolphs H. D., Steffens L.: Correlation between tumour stage, tumour grade
- and Immunocompetence in patients with carcinoma of the bladder and prostate. Eur.
- Urol., 1977, 3, 23. ? 2. Brosman S., Hausman M., Shacks S.: Immunologic alteration
- in patients with prostatic carcinoma. J. Urol., 1975, 113, 841. ? 3. Catalona W. J.,
- Potvin C, Chretien P. B.: T lymphocytes in bladder and prostatic cancer patients.
- J. Urol., 1974, 112, 378. ? 4. Catalona W. J., Smolev J. K., Harty J. I.: Prognostic
- value of host immunocompetence in urologic cancer patients. J. Urol., 1975, 114,
- 922. ? 5. Droller M. J.: Immunotherapy and genitourinary neoplasma. Symposium
- on eontroverisies in urologic onkology. Urol. Clin. N. A., 1980, 7, 831. ? 6. Javad-
- pour N.: Immunology of genitourinary cancer. Recent advances in urologic cancer.
- Williams ? Wilkins, Baltimore, London, 1982, 5, 94. ? 7. Kwinta A.; Próba oceny
- reaktywności immunologicznej u chorych na raka nerki z przerzutami. Urol. Pol.,
- 1983, 4, 323. ? 8. Leńko J., Turowski G., Dobrowolski Z.: Delayed-type hypersen-
- sitivity in patients with nodular hyperplasia and carcinoma of the prostate. Acta
- Med. Pol., 1983, 24, 93. ? 9. Leńko J., Bugajski A., Augustyn M.: Przezodbytnicza
- biopsja cienkoigłowa w diagnostyce raka stercza. Urol. Pol., 1983, 4, 260. ? 10.
- Mc Laughlin A. P., Kessler W. O., Triman K. K., Gites R. F.: Immunologic com
- petence in patients with urologic cancer. J. Urol., 1974, 111, 233.
- 11. Newberry W. M., Sandford J. P.: Defective cellular immunity in renal
- failure: depresion of reactivity of lymphocytes to phytohemagglutinin by renal
- failure serum. J. Clin. Invest., 1971, 50, 1262. ?12. Robinson M. R., Nakhla L. S.,
- Whitaker R. H.: A new concept in the management of carcinoma of the prostate.
- Brit. J. Urol., 1971, 43, 728. ? 13. Sakai H., Daniels J. C, Remmiers A. R., Sarles
- H. E? Fish J. C, Cobb E. K., Levin W. C, Ritzman S. E.: In vitro reactivity of
- human lymphocytes in Chronic uraemia: analysis and interpretation. Clin. Exp.
- Immunol., 1971, 8, 213. ? 14. Sengar D. P., Rashid A., Harris J. E.: In vitro reacti-
- vity of lymphocytes obtained from patients maintained by haemodialysis. Clin.
- Exp. Immunol., 1975, 21, 298. ? 15. Stefani S. S., Menon M., Conning J. R., Clark
- S. S.: Cell mediated immune competence in patients with prostatic carcinoma. J.
- Urol., 1978, 120, 431. ? 16. Thomas J. W., Jerkins G., Cox G? Lieberman P.: De-
- fective cell mediated immunity in carcinoma of the prostate. Invest. Urol., 1976,
- 14, 72. ? 17. Turowski G.: Proste metody określania T limfocytów w testach roze-
- towch (TE). Przeg. Metod. AM w Krakowie, 1975, 10, 29. ? 18. Turowski G., Ka-
- pińska-Mrówka M., Indyk E.: Badania nad reaktywnością immunologiczną chorych
- na łuszczycę zwykłą. III. Względna aktywność rozetowa limfocytów i ich proporcje
- w przebiegu klinicznym oraz w zależności od ekspresji antygenów HLA. Przeg.
- Dermat., 1981, 68, 1. ? 19. Whitmore W. F.: The natural history of prostatic cancer. Cancer, 1973, 32, 1104. ? 20. Wybran J., Fudenberg H. H.: Thymus derived rosette--fonming cells. New Engl. J. Med., 1973, 288, 1072.
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