PTU - Polskie Towarzystwo Urologiczne
list of articles:

THE ROLE OF ALPHA-FETOPROTEIN (AFP) AND CHORIONIC GONADOTROPIN (hCG) IN THE DIAGNOSIS TREATMENT MONITORING, AND FOLLOW-UP OF PATIENTS WITH TESTICULAR GERM CELL TUMOURS
Article published in Urologia Polska 1987/40/4.

authors

Janusz J. Szymendera, Jan Leńko, Grzegorz Madej, Ludwika Sikorowa, Janina A. Kamlnska
Z Zakładu Medycyny Nuklearnej, Patologii, Przychodni Centrum Onkologii ? Instytutu im. M. Skłodowskiej-Curie w Warszawie
Dyrektor: prof. dr hab. med. J. Steffen Z Kliniki Urologii AM im. M. Kopernika w Krakowie Kierownik: prof. dr hab. med. J. Leńko

summary

Serum levels of AFP and hCG were determined in 145 patients before and serially after orchidectomy, and in 352 patients only after orchidectomy. Retroperi­toneal lymph node dissection was performed in 127 patients with nonseminomatous germ cell tumours. A part of seminomas produced smali amounts of hCG. Out of nonseminomatous germ cell tumours, pure teratomas or teratomas with adrnixture of seminomatous elernents produced smali amounts of AFP and/or hCG, chorionic carcinoma produced a lot of hCG, yolk sac tumour ? a lot of AFP, and compound tumours synthesized a lot of AFP and/or hCG. Radiographic and ultrasonographic examinations as well as determinations of concentrations of both markers were parts of the diagnostic-therapeutic strategy: establishing diagnosis, determining progression, and monitoring treatment (surgery, chemotherapy, radiotherapy) and follow-up.
Determination of concentrations of both markers enabled early detection of recurrence in patients with nonseminomatous germ cell tumours.

references

  1. 1. Bracken R. B., Johnson D.E., Frazier O. H., Logothetis C.J., Trindade A.,
  2. Samuels M. L.: The role of surgery following chemotherapy in stage III germ
  3. cell neoplasms. J. Urol., 1983, 129, 39. ? 2. Butcher D. N., Gregory W. M, Gunter
  4. P. A., Masters J. R. W., Parkinson M. C: The biological and clinical significance
  5. of HCG-containing cells in seminoma. Br. J. Cancer, 1985, 51, 473. ? 3. Javad-
  6. pour N.: The role of bio1ogic tumor markers in testicular cancer. Cancer, 1980, 45,
  7. 1755. ? 4. Kamer M., Rowland R.G., Einhorn L.H., Donohue J.P.: Recurrent tes­
  8. tis cancer: seeding from retroperitoneal nodes after complete remissions by che­
  9. motherapy. J.Urol., 1983, 130, 1196. ? 5. Kurman R. J., Scardino P.T., Mclntire K.
  10. R., Walamann T. A., Javadpour N.: Cellular localization of alpha-fetoprotein and
  11. human chorionic gonadotropin in germ cell tumors of the testis using an indirect
  12. immunoperoxidase techniąue. Cancer, 1977, 40, 2136. ? 6. Kusuda L., Leidich R. B.,
  13. Das S.: Mature teratoma of the testis metastasizing as mature teratoma. J. Urol.,
  14. 1986, 135, 1020. ? 7. Loehrer P. J., Sr., Hui S., Clark S., Seal M., Einhorn L. U.,
  15. Wiliams S. D., Ulbright T., Mandelbaum I., Rowland R., Donohiie J. P.: Teratoma
  16. following cisplatin-based Combination chemotherapy for nonseminomatous germ
  17. cell tumors: a clonicopathological correlation. J.Urol., 1986, 135, 1183. ? 8. Madej G.,
  18. Didkowska J, Zatoński W.: Epidemiologia nowotworów złośliwych jądra w Polsce.
  19. Epidemiologiczna analiza umieralności. Nowotwory, 1984, 34, 245. ? 9. Maier J. G.,
  20. Sulak M. H.: Radiation therapy in malignant testis tumors. Part I Seminoma. Can­
  21. cer, 1973, 32, 1212. ? 10. Molenaar W.M., Oosterhuis J.W., Meiring A., Sleyfer
  22. D. T., Schraffordt Koops H., Cornelisse C. J.: Histology and DNA contents of a se­
  23. condary malignancy arising in a mature residual lesion six years after chemo­
  24. therapy for a disseminated nonseminomatous testicular tumor, Cancer, 1986, 58, 264.
  25. 11. Mostofi F. K., Sobin L. H.: Histological typing of testis tumours. Internatio­
  26. nal histological classification of tumours No. 16. World Health Organization. Ge-
  27. neva, 1977. ? 12. Reynoso G.: CEA: basic concepts, clinical applications. Diagnos­
  28. tic Med., 1981, 4, 41. ? 13. Ruoslahti E., Seppala M.: Studies of carcino-fetal pro­
  29. teins. III. Development of a radioimmunoassay for alpha-fetoprotein. Demonstra­
  30. tion of alpha-fetoprotein in serum of healthy human adults. Int. J. Cancer, 1971,
  31. 8, 374. ? 14. Szymendera J. J., Zborzil J., Sikorowa L., Kamińska J. A., Gadek A.:
  32. Value of five tumor markers (AFP, CEA, hCG, hPL and SPI) in diagnosis and
  33. staging of testicular germ cell tumours. Oncology, 1981, 38, 222. ? 15. Szymendera
  34. J. J., Zborzil J., Sikorowa L., Leńko J., Kamińska J. A., Gadek A.: Evaluation of
  35. five tumor markers (AFP, CEA, hCG, hPL and SPI) in monitoring therapy and
  36. follow-up of patients with testicular germ cell tumors. Oncology, 1983, 40, 1. ? 16.
  37. Talerman A.: The incidence of yolk sac tumor (endodermal sinus tumor) elernents
  38. in germ cell tumors of the testis in adults. Cancer, 1975, 36, 211. ? 17. Taler­
  39. man A., Haije W. G: Alphafetoprotein and germ cell tumors: a possible role of
  40. yolk sac tumor in production of alpha-fetoprotein. Cancer, 1974, 34, 1722. ? 18.
  41. Vaitukaitis J L, Braunstein G. D., Ross G. T.: A radioimmunoassay which speci-
  42. ficaUy measures human chorionic gonadotropin in the presence of human luteini­
  43. zing hormone. Am. J. Obstet. Gynecol., 1972, 113, 751. ? 19. Wittekind C, Wich-
  44. mann T, von Kleist S.: Immunohistological localization of AFP and hCG in uni-
  45. form"y classified testis tumors. Anticancer Res., 1983, 3, 327.